Dapoxetine

Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI). Higher serotonin levels in the brain pathway that controls ejaculation delay the ejaculatory reflex. Unlike conventional SSRIs used for depression, dapoxetine is rapidly absorbed and rapidly cleared — designed specifically for on-demand use.

Typically 1–3 hours before. Peak plasma concentration is reached in around 1–1.5 hours. Take with at least a full glass of water to reduce the risk of lightheadedness.

Dapoxetine has a short half-life (~1.5 hours for the rapid-clearance component, ~20 hours for a slower component). The clinical effect window covers intimacy for the evening, and you should not take a second dose within 24 hours.

No. The dapoxetine licence says it should not be used by men who are taking a PDE5 inhibitor, because the combination reduces your tolerance to standing up quickly and raises the risk of fainting. If you have both erectile dysfunction and premature ejaculation, we can only treat erectile dysfunction; if premature ejaculation persists, please see your GP.

Don't double the dose yourself. Message the pharmacist team — they may step you up to 60 mg if 30 mg has been insufficient for at least 4 weeks and well tolerated. A very small subset of men respond better at 60 mg.

No — dapoxetine is not a PDE5 inhibitor and does not act on erection. If you have both PE and ED, the two medicines are not taken together, and we can only treat erectile dysfunction; if premature ejaculation persists, please see your GP.

No — dapoxetine is licensed for on-demand use only, with a maximum of one dose per 24 hours and not every day. Continuous daily SSRIs are a different treatment approach used off-label for PE under specialist supervision.

Nausea, dizziness, headache, diarrhoea, and insomnia are the most frequently reported. Most are mild to moderate and dose-related. Stay well hydrated before and after taking a dose — this reduces the risk of fainting (vasovagal syncope).

No — absolutely not. Combining with other SSRIs, SNRIs, tricyclics, MAOIs, tramadol, St John's wort, or other serotonergic agents risks serotonin syndrome, which is a medical emergency. Disclose all medications at consultation.

No. Dapoxetine should not be used while you are taking a PDE5 inhibitor: both can lower blood pressure on standing, and the combination raises the risk of dizziness and fainting. Tell us at consultation if you already use an ED tablet, and never combine the two on your own initiative.

Dapoxetine can cause vasovagal syncope (fainting), especially with dehydration. Drink a full glass of water with your dose, avoid alcohol, and sit or lie down if you feel lightheaded. The risk is highest in the first 3 hours after dosing.

Avoid or minimise alcohol. Alcohol worsens the lightheadedness and syncope risk, and is independently a common contributor to sexual dysfunction.

Dapoxetine is not suitable if you have a history of mania, severe depression, or are currently on an antidepressant. The pharmacist screens for this at consultation. If you have depression symptoms, a GP or mental-health review is the right route — dapoxetine is not a treatment for depression.

Licensed for men aged 18–64. Use outside that range requires specialist review. The pharmacist checks age, cardiovascular and mental-health profile before prescribing.

In discreet, unbranded packaging with a generic sender name, sent by DPD tracked delivery.

Both options are available. Many patients order small packs (typically 3 tablets) as needed; others set up repeat orders for convenience.

No — store at room temperature, away from direct sunlight and moisture.

Any time. Pause, skip, or cancel from your Caremacy account with no notice period or fees.

A qualified prescriber reviews every request. Dapoxetine is prescription-only, and cardiovascular, mental-health, and interaction risks are reviewed before prescribing. Treatment is declined where inappropriate.

Yes. Consultations and medical data are stored securely under UK GDPR. Only the pharmacists involved in your care access them. Nothing is shared with third parties for marketing.

We recommend telling your GP, especially if you take any other prescription medicines or have a cardiovascular or mental-health history. We can send a record to your GP with your explicit consent.

Yes, via secure messaging in your Caremacy dashboard. For severe symptoms (agitation + fever + muscle rigidity suggesting serotonin syndrome, fainting, or severe allergic reaction) stop treatment and seek urgent medical attention immediately.